Call For Paper Volume:4 Issue:10 Oct'2017 |

OPTIMAL CONTROL STRATEGIES AND COST-EFFECTIVENESS ANALYSIS OF HCV MODEL IN TANZANIA

Publication Date : 12/12/2015



Author(s) :

Neterindwa Ainea , Estomih S. Massawe , Oluwole, Daniel Makinde , Lucy Namkinga.


Volume/Issue :
Volume 2
,
Issue 12
(12 - 2015)



Abstract :

The aim of this paper is to investigate the effectiveness and cost-effective of two HCV preventive measures i.e. (i) education, health care and immunization (ii) treatment. The local and global stability of the disease free equilibrium is established. It is noted that the disease-free equilibrium point is locally stable whenever basic reproduction number. Also, the model has a unique HCV-persistent equilibrium whenever, implying the persistence of endemic disease in the community. As with many models, the model presented in this article should be treated with circumspection because of the assumptions made and the difficulty in the estimation of the model parameters. Pontryagin’s Maximum Principle is used to derive necessary conditions for the optimal control of the disease. The Infection Averted ratio and the Incremental Cost-Effectiveness Ratio (ICER) are calculated to investigate the cost-effectiveness of all possible combinations of the two control measures. Results revealed among others that the most cost-effective strategy for HCV control is the treatment of infected individuals. Therefore, more efforts from policy-makers on the provisions of treatment of infectives would go a long way to combat the HCV epidemic.


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OPTIMAL CONTROL STRATEGIES AND COST-EFFECTIVENESS ANALYSIS OF HCV MODEL IN TANZANIA

December 7, 2015