Call For Paper Volume:4 Issue:10 Oct'2017 |

2D CAT Based Modeling of Tumour Growth and Drug Transport

Publication Date : 31/01/2015



Author(s) :

Kalyani Bodake , S.P.Sonavane.


Volume/Issue :
Volume 2
,
Issue 1
(01 - 2015)



Abstract :

The transition of normal cells in the tissue that leads into tumour and spreads throughout depending upon its behavioural conditions is a complex biological process studied through the use of both in vivo and in vitro experimentation. Mathematical models provide the approach by using a controlled environment in which a system can be described quantitatively. This can also yield data which predicts the behaviour of cells and likely medical conditions after thorough analysis by the modeller. In an effort to study the characteristics that increase cell fitness, the paper presents a 2D Cellular Automaton model that uses computer simulation to describe the invasion of healthy tissue by cancer cells. The growth process is simulated and it was found that movement of cells affects tumour growth rate. It was also found that the relative distance of the tumour initiation area from neighbouring vessels influences the growth of tumour. The model and the simulation software developed thus can be used to understand the dynamics of early tumour growth and to explore various hypotheses of tumour growth relevant to drug delivery in chemotherapy. Importantly, this approach highlights that vessel displacement should not be neglected in tumour growth models. The paper thus presents two models i.e cancer growth model and drug transport model for tumour growth and treatment that will help to diagnose the early tumour growth. Though cancer is uncurable;early and quick detection of cancer will help doctors in better way by suggesting quick remedial action against it.


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2D CAT Based Modeling of Tumour Growth and Drug Transport

January 31, 2015